APSD of Soft Mist Inhalers (SMIs)

For SMIs as for nebulisers, the evaporation of droplets exacerbated by the thermal mass of the impactor can be a problem. Loss of solvent reduces droplet size, producing artificially low APSD measurements, compromising the integrity of the resulting data. Cooling the impactor to approximately 5°C is the recommended method for overcoming this problem. Classified as active devices, the recommended flow rate for ADI testing is 28.3 L/min for the ACI or 30 L/min for the NGI.

SMIs
SMIs

Please select an option:

Next Generation Impactor (NGI) Andersen Cascade Impactor (ACI)
Learn More

Please select an option:

Next Generation Impactor (NGI) Andersen Cascade Impactor (ACI)
Learn More

Related Applications

We also offer a range of equipment for additional ADI support:

Related Applications

Two factors have been identified as being critical to improving the clinical relevance of DDU testing and APSD measurement: realistic breathing profiles and realistic throat and nasal models.

View More

IVIVC Test Systems for DDU and APSD

Two factors have been identified as being critical…

View More

Related Applications

Cold Freon®” effect is the inadvertent reaction to the chilling sensation that hits the back of the throat following actuation of usually MDIs or Nasal devices.

View More

Cold Freon® Effect

Cold Freon®” effect is the inadvertent reaction…

View More

Related Applications

USP monographs are most commonly used for product release testing, but may also be considered during product development.

View More

USP Monographs (Generic Drug Development)

USP monographs are most commonly used for product …

View More

Semi-Automation Tools

Improve efficiency
Reduce variability
Eliminate handling error
Increase testing capacity

Semi-Automation Tools

Copley supplies a broad range of labour-saving devices and semi-automated systems for Aerodynamic Particle Size Distribution applications.

View Product Range

Sample Preparation Unit SPU 200i

Copley supplies a broad range of labour-saving dev…

View Product Range

Semi-Automation Tools

Copley supplies a broad range of labour-saving devices and semi-automated systems for Aerodynamic Particle Size Distribution applications.

View Product Range

Impactor Cleaning System

Copley supplies a broad range of labour-saving dev…

View Product Range

How Does a Cascade Impactor Work?

Play Video

Related Services

Training

Training

We offer a range of training courses, presentations and seminars covering a wide range of topics.

Find Out More
Training

Servicing

A comprehensive range of both in-house and on-site product servicing options are available

Find Out More
Training

Support

Our team of experienced technicians and engineers are on hand to help and advise

Find Out More

Related News & Resources

Copley introduces the new Flow Rate Sensor, a dedicated device for inhaler testing systems.

27th June 2023

Find out more

Copley’s appointment of new Applications Specialist, Clair Brooks, highlights commitment to exemplary customer support.

23rd May 2023

Find out more

Introducing the Copley Impactor Genie™ IG 200i, a two-in-one solution for quicker, more efficient inhaled product testing

25th April 2023

Find out more

Copley launches EnviroMate™, an efficient, benchtop environmental chamber for inhaler testing

14th September 2022

Find out more

Copley launches a new semi-automation tool for inhaled product testing

28th April 2022

Find out more

Copley Scientific joins the Industries Forum of the Taskforce for Lung Health

22nd June 2021

Find out more

Introducing Inhalytix®: a new solution for analysing and managing inhaler test data from Copley

18th March 2021

Find out more

Copley announces a major upgrade of the world’s ‘go to’ inhaler testing portfolio

1st March 2021

Find out more

New e-Training service from Copley for pharmaceutical testing

29th January 2021

Find out more

Advancing the science of OINDPs: Copley Scientific joins IPAC-RS

28th February 2018

Find out more

Confused about cascade impaction? Watch the new animations from Copley Scientific to improve your understanding of inhaled drug product testing.

22nd August 2016

Find out more

New maintenance tools from Copley Scientific help optimise inhaler testing

30th June 2009

Find out more

New, state-of-the-art vision system central to Copley Scientific’s cascade impactor validation service

24th July 2007

Find out more

Understanding the Links Between Drug Delivery Route and In Vitro Test Methods

View download

Reducing Inhaler Testing Variability Through Test Environment Control

View download

Semi-Automating Inhaler Testing – A Good Idea, but Where to Start?

View download

Putting Inhalers to the Test

View download

A short Q&A with our CEO, Mark Copley, On Inhaled Product Testing

View download

Semi-Automation in Inhaler Testing – Exploring the Potential and Practicalities

View download

Optimizing the Role of Automation in Variability Reduction Strategies For Delivered Dose Uniformity (DDU) and Aerodynamic Particle Size Distribution (APSD) Testing of Inhaled Drug Products

View download

The Regulatory Landscape for OINDPs – The Biggest Shake-up in A Generation?

View download

ONdrugDelivery Article: December 2018Variability in Cascade Impaction: Sources, Impact and Strategies for Reduction

View download

Optimizing the Application of In Vitro Test Methods for the Demonstration of Bioequivalence in Orally Inhaled Products

View download

Demonstrating Bioequivalence of Orally Inhaled Products

View download

Optimising the Application of In Vitro Test Methods for the Demonstration of BE in OIPs

View download